PD-1 gene polymorphisms and thyroid expression of PD-1 ligands differ between Graves’ and Hashimoto’s diseases

PD-1 gene polymorphisms and thyroid expression of PD-1 ligands differ between Graves’ and Hashimoto’s diseases

The programmed cell death-1 (PD-1)/PD ligand pathway plays a key role in the maintenance of peripheral tolerance by enhancing the suppressive activity of regulatory T (Treg) cells. The promoter activity of the A allele of PD1 rs36084323 G/A polymorphism is lower than that of the G allele. We examine...

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Bibliographic Details
Main Authors: Mayumi Kawabata, Naoya Inoue, Mikio Watanabe, Ayaka Kobayashi, Yoh Hidaka, Akira Miyauchi, Yoshinori Iwatani
Format: Article
Language:English
Published: Taylor & Francis Group 2021-10-01
Series:Autoimmunity
Subjects:
pd-1
pd-l1
pd-l2
regulatory t cell
single nucleotide polymorphism
severity
Online Access:http://dx.doi.org/10.1080/08916934.2021.1946796

Internet

http://dx.doi.org/10.1080/08916934.2021.1946796

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