Shrimp miR-965 induced the human melanoma stem-like cell apoptosis and inhibited their stemness by disrupting the MCL-1-ER stress-XBP1 feedback loop in a cross-species manner

Shrimp miR-965 induced the human melanoma stem-like cell apoptosis and inhibited their stemness by disrupting the MCL-1-ER stress-XBP1 feedback loop in a cross-species manner

Abstract Background Melanoma is a type of aggressive skin cancer with a poor survival rate. The resistance to conventional therapy of this disease is, at least in part, attributed to its cancer stem cell population. However, the mechanism of survival and stemness maintenance of cancer stem cells rem...

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Bibliographic Details
Main Authors: Wenlin Wu, Chenxi Xu, Xiaobo Zhang, An Yu, Le Shu
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Stem Cell Research & Therapy
Subjects:
Melanoma stem-like cells
Myeloid cell leukemia sequence 1 (MCL-1)
Shrimp miR-965
X-box-binding protein 1 (XBP1)
Cross-species gene expression regulation
Online Access:http://link.springer.com/article/10.1186/s13287-020-01734-3

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http://link.springer.com/article/10.1186/s13287-020-01734-3

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