Pulsed Electric Fields Induce STING Palmitoylation and Polymerization Independently of Plasmid DNA Electrotransfer

Pulsed Electric Fields Induce STING Palmitoylation and Polymerization Independently of Plasmid DNA Electrotransfer

Gene therapy approaches may target skeletal muscle due to its high protein-expressing nature and vascularization. Intramuscular plasmid DNA (pDNA) delivery via pulsed electric fields (PEFs) can be termed electroporation or electrotransfer. Nonviral delivery of plasmids to cells and tissues activates...

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Bibliographic Details
Main Authors: Amanda Sales Conniff, Julie Singh, Richard Heller, Loree C. Heller
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Pharmaceutics
Subjects:
skeletal muscle
STING
palmitoylation
pulsed electric fields
electroporation
electrotransfer
Online Access:https://www.mdpi.com/1999-4923/16/3/363

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https://www.mdpi.com/1999-4923/16/3/363

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