Highly secreted tryptophanyl tRNA synthetase 1 as a potential theranostic target for hypercytokinemic severe sepsis

Highly secreted tryptophanyl tRNA synthetase 1 as a potential theranostic target for hypercytokinemic severe sepsis

Abstract Despite intensive clinical and scientific efforts, the mortality rate of sepsis remains high due to the lack of precise biomarkers for patient stratification and therapeutic guidance. Secreted human tryptophanyl-tRNA synthetase 1 (WARS1), an endogenous ligand for Toll-like receptor (TLR) 2...

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Bibliographic Details
Main Authors: Yoon Tae Kim, Jin Won Huh, Yun Hui Choi, Hee Kyeong Yoon, Tram TT Nguyen, Eunho Chun, Geunyeol Jeong, Sunyoung Park, Sungwoo Ahn, Won-Kyu Lee, Young-Woock Noh, Kyoung Sun Lee, Hee-Sung Ahn, Cheolju Lee, Sang Min Lee, Kyung Su Kim, Gil Joon Suh, Kyeongman Jeon, Sunghoon Kim, Mirim Jin
Format: Article
Language:English
Published: Springer Nature 2023-12-01
Series:EMBO Molecular Medicine
Subjects:
Sepsis
Theranostics
Tryptophanyl-tRNA Synthetase (WARS1)
Hypercytokinemia
Anti-WARS1 Antibody
Online Access:https://doi.org/10.1038/s44321-023-00004-y

Internet

https://doi.org/10.1038/s44321-023-00004-y

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