Unified mechanisms for self-RNA recognition by RIG-I Singleton-Merten syndrome variants

Unified mechanisms for self-RNA recognition by RIG-I Singleton-Merten syndrome variants

The innate immune sensor retinoic acid-inducible gene I (RIG-I) detects cytosolic viral RNA and requires a conformational change caused by both ATP and RNA binding to induce an active signaling state and to trigger an immune response. Previously, we showed that ATP hydrolysis removes RIG-I from lowe...

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Bibliographic Details
Main Authors: Charlotte Lässig, Katja Lammens, Jacob Lucián Gorenflos López, Sebastian Michalski, Olga Fettscher, Karl-Peter Hopfner
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-07-01
Series:eLife
Subjects:
RIG-I
RLR
innate immune system
ATPase domain
autoimmune response/disease
Singleton-Merten syndrome
Online Access:https://elifesciences.org/articles/38958

Internet

https://elifesciences.org/articles/38958

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