Sildenafil delays bone remodeling of fractured femora in aged mice by reducing the number and activity of osteoclasts within the callus tissue

Sildenafil delays bone remodeling of fractured femora in aged mice by reducing the number and activity of osteoclasts within the callus tissue

The elderly exhibit a reduced healing capacity after fracture, which is often associated with delayed or failed bone healing. This is due to a plethora of factors, such as an impaired bone vascular system and delayed angiogenesis. The phosphodiesterase-5 (PDE-5) inhibitor sildenafil exerts pro-angio...

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Bibliographic Details
Main Authors: Maximilian M. Menger, Maximilian Emmerich, Claudia Scheuer, Sandra Hans, Benedikt J. Braun, Steven C. Herath, Mika F. Rollmann, Michael D. Menger, Matthias W. Laschke, Tina Histing
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Sildenafil
Aging
Fracture healing
Angiogenesis
OPG
Mice
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224001720

Internet

http://www.sciencedirect.com/science/article/pii/S0753332224001720

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