Liquid-Ordered Phase Formation by Mammalian and Yeast Sterols: A Common Feature With Organizational Differences

Liquid-Ordered Phase Formation by Mammalian and Yeast Sterols: A Common Feature With Organizational Differences

Here, biophysical properties of membranes enriched in three metabolically related sterols are analyzed both in vitro and in vivo. Unlike cholesterol and ergosterol, the common metabolic precursor zymosterol is unable to induce the formation of a liquid ordered (lo) phase in model lipid membranes and...

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Bibliographic Details
Main Authors: Alena Khmelinskaia, Joaquim M. T. Marquês, André E. P. Bastos, Catarina A. C. Antunes, Andreia Bento-Oliveira, Silvia Scolari, Gerson M. da S. Lobo, Rui Malhó, Andreas Herrmann, H. Susana Marinho, Rodrigo F. M. de Almeida
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ergosterol
cholesterol
zymosterol
fluorescence lifetime imaging microscopy
fluorescence spectroscopy
plasma membrane
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00337/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00337/full

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