Spike substitution T813S increases Sarbecovirus fusogenicity by enhancing the usage of TMPRSS2.

Spike substitution T813S increases Sarbecovirus fusogenicity by enhancing the usage of TMPRSS2.

SARS-CoV Spike (S) protein shares considerable homology with SARS-CoV-2 S, especially in the conserved S2 subunit (S2). S protein mediates coronavirus receptor binding and membrane fusion, and the latter activity can greatly influence coronavirus infection. We observed that SARS-CoV S is less effect...

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Bibliographic Details
Main Authors: Yong Ma, Pengbin Li, Yunqi Hu, Tianyi Qiu, Lixiang Wang, Hongjie Lu, Kexin Lv, Mengxin Xu, Jiaxin Zhuang, Xue Liu, Suhua He, Bing He, Shuning Liu, Lin Liu, Yuanyuan Wang, Xinyu Yue, Yanmei Zhai, Wanyu Luo, Haoting Mai, Yu Kuang, Shifeng Chen, Feng Ye, Na Zhou, Wenjing Zhao, Jun Chen, Shoudeng Chen, Xiaoli Xiong, Mang Shi, Ji-An Pan, Yao-Qing Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-05-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1011123

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https://doi.org/10.1371/journal.ppat.1011123

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