Enhancement of Skin Permeability Prediction through PBPK Modeling, Bayesian Inference, and Experiment Design

Enhancement of Skin Permeability Prediction through PBPK Modeling, Bayesian Inference, and Experiment Design

Physiologically based pharmacokinetic (PBPK) models of skin absorption are a powerful resource for estimating drug delivery and chemical risk of dermatological products. This paper presents a PBPK workflow for the quantification of the mechanistic determinants of skin permeability and the use of the...

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Bibliographic Details
Main Authors: Abdullah Hamadeh, Abdulkarim Najjar, John Troutman, Andrea Edginton
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Pharmaceutics
Subjects:
dermal
skin
modeling
pharmacokinetics
Bayesian
mechanistic
Online Access:https://www.mdpi.com/1999-4923/15/12/2667

Internet

https://www.mdpi.com/1999-4923/15/12/2667

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