Nrf2 regulates downstream genes by targeting miR-29b in severe asthma and the role of grape seed proanthocyanidin extract in a murine model of steroid-insensitive asthma

Nrf2 regulates downstream genes by targeting miR-29b in severe asthma and the role of grape seed proanthocyanidin extract in a murine model of steroid-insensitive asthma

Context Grape seed proanthocyanidin extract (GSPE) is effective in treating severe asthma (SA). Objective To examine the relationship between Nrf2-miR-29b axis and SA, and to detect whether preventive use of GSPE relieves SA via it. Materials and methods We recruited 10 healthy controls, 10 patients...

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Bibliographic Details
Main Authors: Yan Qian, Yun Sun, Yi Chen, Zhengdao Mao, Yujia Shi, Di Wu, Bin Gu, Zhiguang Liu, Qian Zhang
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Pharmaceutical Biology
Subjects:
steroid insensitivity
nuclear factor erythroid 2-related factor 2
airway inflammation
Online Access:http://dx.doi.org/10.1080/13880209.2022.2032205

Internet

http://dx.doi.org/10.1080/13880209.2022.2032205

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