Regioselective Hydroxylation of Oleanolic Acid Catalyzed by Human CYP3A4 to Produce Hederagenenin, a Chiral Metabolite

Regioselective Hydroxylation of Oleanolic Acid Catalyzed by Human CYP3A4 to Produce Hederagenenin, a Chiral Metabolite

Oleanolic acid (OA) is a pentacyclic triterpenoid widely found in plants and foods as an aglycone of triterpenoid saponins or as a free acid. OA exhibits beneficial activities for humans, including antitumor, antivirus, and hepatoprotection properties without apparent toxicity. The metabolites produ...

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Bibliographic Details
Main Authors: Ngoc Tan Cao, Ngoc Anh Nguyen, Thien-Kim Le, Gun Su Cha, Ki Deok Park, Chul-Ho Yun
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Catalysts
Subjects:
biocatalyst
C-H hydroxylation
hederagenin
human CYP3A4
regioselective hydroxylation
oleanolic acid
Online Access:https://www.mdpi.com/2073-4344/11/2/267

Internet

https://www.mdpi.com/2073-4344/11/2/267

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