PROMOTER POLYMORPHISM -857С>T OF TNFα GENE AND EFFICACY OF ANTICYTOKINE THERAPY IN PATIENTS WITH RHEUMATOID ARTHRITIS

PROMOTER POLYMORPHISM -857С>T OF TNFα GENE AND EFFICACY OF ANTICYTOKINE THERAPY IN PATIENTS WITH RHEUMATOID ARTHRITIS

Abstract. Prevalence of TNFα gene promoter polymorphism at -857 position was investigated in normal persons and among patients with rheumatoid arthritis. We detected a relation of this polymorphism to the levels of TNFα production by mononuclear cells of healthy donors. Changes in relative frequenci...

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Bibliographic Details
Main Authors: A. N. Silkov, N. S. Shkaruba, T. A. Kalashnikova, L. P. Sizyakina, J. B. Shulman, S. V. Dolgikh, V. I. Mazurov, O. A. Gerzog, A. E. Sizikov, V. A. Kozlov, S. V. Sennikov
Format: Article
Language:Russian
Published: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 2014-07-01
Series:Медицинская иммунология
Subjects:
allelic polymorphism
tnfα, rheumatoid arthritis
anticytokine therapy
Online Access:https://www.mimmun.ru/mimmun/article/view/300

Internet

https://www.mimmun.ru/mimmun/article/view/300

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