The Discovery of the Fucoidan-Active Endo-1→4-α-L-Fucanase of the GH168 Family, Which Produces Fucoidan Derivatives with Regular Sulfation and Anticoagulant Activity

The Discovery of the Fucoidan-Active Endo-1→4-α-L-Fucanase of the GH168 Family, Which Produces Fucoidan Derivatives with Regular Sulfation and Anticoagulant Activity

Sulfated polysaccharides of brown algae, fucoidans, are known for their anticoagulant properties, similar to animal heparin. Their complex and irregular structure is the main bottleneck in standardization and in defining the relationship between their structure and bioactivity. Fucoidan-active enzym...

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Bibliographic Details
Main Authors: Artem S. Silchenko, Ilya V. Taran, Roza V. Usoltseva, Nikolay V. Zvyagintsev, Anastasiya O. Zueva, Nikita K. Rubtsov, Dana E. Lembikova, Olga I. Nedashkovskaya, Mikhail I. Kusaykin, Marina P. Isaeva, Svetlana P. Ermakova
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:International Journal of Molecular Sciences
Subjects:
GH168 family
fucoidan-degrading gene cluster
recombinant fucanase
fucoidanase
<i>Fucus evanescens</i>
fucoidan derivatives
Online Access:https://www.mdpi.com/1422-0067/25/1/218

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https://www.mdpi.com/1422-0067/25/1/218

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