Detection of the onset of ischemia and carcinogenesis by hypoxia-inducible transcription factor-based in vivo bioluminescence imaging.

Detection of the onset of ischemia and carcinogenesis by hypoxia-inducible transcription factor-based in vivo bioluminescence imaging.

An animal model for the early detection of common fatal diseases such as ischemic diseases and cancer is desirable for the development of new drugs and treatment strategies. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that regulates oxygen homeostasis and plays key roles in a number...

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Bibliographic Details
Main Authors: Tetsuya Kadonosono, Takahiro Kuchimaru, Shuichi Yamada, Yumi Takahashi, Atsushi Murakami, Taeko Tani, Hitomi Watanabe, Tomoharu Tanaka, Kiichi Hirota, Masahiro Inoue, Tetsuya Tsukamoto, Takeshi Toyoda, Koji Urano, Kazuhiko Machida, Tomoo Eto, Tomoyuki Ogura, Hideki Tsutsumi, Mamoru Ito, Masahiro Hiraoka, Gen Kondoh, Shinae Kizaka-Kondoh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3213102?pdf=render

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http://europepmc.org/articles/PMC3213102?pdf=render

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