Deterministic and Stochastic Cellular Mechanisms Contributing to Carbon Monoxide Induced Ventricular Arrhythmias

Deterministic and Stochastic Cellular Mechanisms Contributing to Carbon Monoxide Induced Ventricular Arrhythmias

Chronic exposure to low levels of Carbon Monoxide is associated with an increased risk of cardiac arrhythmia. Microelectrode recordings from rat and guinea pig single isolated ventricular myocytes exposed to CO releasing molecule CORM-2 and excited at 0.2/s show repolarisation changes that develop o...

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Bibliographic Details
Main Authors: Moza M. Al-Owais, Derek S. Steele, Arun V. Holden, Alan P. Benson
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
carbon monoxide
ion channels
arrhythmias
modeling
potassium channels
action potential duration
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.651050/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.651050/full

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