Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction

Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction

Mitochondrial dysfunction causes the production of reactive oxygen species (ROS) and oxidative damage, and oxidative stress and inflammation are considered key factors causing intervertebral disc degeneration (IVDD). Thus, restoring the mitochondrial dysfunction is an attractive strategy for treatin...

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Bibliographic Details
Main Authors: Zhanqiu Dai, Chen Xia, Tingxiao Zhao, Haoli Wang, Hongsen Tian, Ouyuan Xu, Xunbin Zhu, Jun Zhang, Pengfei Chen
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Materials Today Bio
Subjects:
Intervertebral disc degeneration
Nucleus pulposus
Platelets
Vesicles
Reactive oxygen species
Mitochondrial dysfunction
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006422003106

Internet

http://www.sciencedirect.com/science/article/pii/S2590006422003106

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