Pathological ultrastructural alterations of myelinated axons in normal appearing white matter in progressive multiple sclerosis

Pathological ultrastructural alterations of myelinated axons in normal appearing white matter in progressive multiple sclerosis

Abstract Multiple sclerosis (MS) pathophysiology includes inflammation, demyelination and neurodegeneration, but the exact mechanisms of disease initiation and progression are unknown. A major feature of lesions is lack of myelin, which increases axonal energy demand and requires adaptation in numbe...

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Bibliographic Details
Main Authors: Wendy Oost, Allard J. Huitema, Kim Kats, Ben N. G. Giepmans, Susanne M. Kooistra, Bart J. L. Eggen, Wia Baron
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Acta Neuropathologica Communications
Subjects:
Electron microscopy
g-ratio
Human brain (bank)
Mitochondria
Multiple sclerosis
Myelin
Online Access:https://doi.org/10.1186/s40478-023-01598-7

Internet

https://doi.org/10.1186/s40478-023-01598-7

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