Rewiring the Metabolic Network to Increase Docosahexaenoic Acid Productivity in Crypthecodinium cohnii by Fermentation Supernatant-Based Adaptive Laboratory Evolution

Rewiring the Metabolic Network to Increase Docosahexaenoic Acid Productivity in Crypthecodinium cohnii by Fermentation Supernatant-Based Adaptive Laboratory Evolution

Docosahexaenoic acid (DHA, 22:6n-3) plays significant roles in enhancing human health and preventing human diseases. The heterotrophic marine dinoflagellate Crypthecodinium cohnii is a good candidate to produce high-quality DHA. To overcome the inhibition caused by the fermentation supernatant in th...

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Bibliographic Details
Main Authors: Liangsen Liu, Jinjin Diao, Yali Bi, Lei Zeng, Fangzhong Wang, Lei Chen, Weiwen Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Microbiology
Subjects:
adaptive laboratory evolution
Crypthecodinium cohnii
growth
DHA content
fermentation supernatant
quantitative proteomics
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.824189/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.824189/full

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