Inhibition of XPO-1 Mediated Nuclear Export through the Michael-Acceptor Character of Chalcones

Inhibition of XPO-1 Mediated Nuclear Export through the Michael-Acceptor Character of Chalcones

The nuclear export receptor exportin-1 (XPO1, CRM1) mediates the nuclear export of proteins that contain a leucine-rich nuclear export signal (NES) towards the cytoplasm. XPO1 is considered a relevant target in different human diseases, particularly in hematological malignancies, tumor resistance, i...

Full description

Bibliographic Details
Main Authors: Marta Gargantilla, José López-Fernández, Maria-Jose Camarasa, Leentje Persoons, Dirk Daelemans, Eva-Maria Priego, María-Jesús Pérez-Pérez
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Pharmaceuticals
Subjects:
chalcones
exportin-1
covalent binding
CovDock
anticancer activity
Online Access:https://www.mdpi.com/1424-8247/14/11/1131

Internet

https://www.mdpi.com/1424-8247/14/11/1131

Similar Items