Inhibition of XPO-1 Mediated Nuclear Export through the Michael-Acceptor Character of Chalcones

Inhibition of XPO-1 Mediated Nuclear Export through the Michael-Acceptor Character of Chalcones

The nuclear export receptor exportin-1 (XPO1, CRM1) mediates the nuclear export of proteins that contain a leucine-rich nuclear export signal (NES) towards the cytoplasm. XPO1 is considered a relevant target in different human diseases, particularly in hematological malignancies, tumor resistance, i...

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Bibliographic Details
Main Authors:	Marta Gargantilla, José López-Fernández, Maria-Jose Camarasa, Leentje Persoons, Dirk Daelemans, Eva-Maria Priego, María-Jesús Pérez-Pérez
Format:	Article
Language:	English
Published:	MDPI AG 2021-11-01
Series:	Pharmaceuticals
Subjects:	chalcones exportin-1 covalent binding CovDock anticancer activity
Online Access:	https://www.mdpi.com/1424-8247/14/11/1131

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