DNA damage triggers squamous metaplasia in human lung and mammary cells via mitotic checkpoints

DNA damage triggers squamous metaplasia in human lung and mammary cells via mitotic checkpoints

Abstract Epithelial transdifferentiation is frequent in tissue hyperplasia and contributes to disease in various degrees. Squamous metaplasia (SQM) precedes epidermoid lung cancer, an aggressive and frequent malignancy, but it is rare in the epithelium of the mammary gland. The mechanisms leading to...

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Bibliographic Details
Main Authors: Lucía San Juan, Ana Freije, Natalia Sanz-Gómez, Beatriz Jiménez-Matías, Cayetano Pleguezuelos-Manzano, J. Ramón Sanz, Ernesto de Diego, Sara Naranjo, Hans Clevers, Alberto Gandarillas
Format: Article
Language:English
Published: Nature Publishing Group 2023-01-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01330-3

Internet

https://doi.org/10.1038/s41420-023-01330-3

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