Synthesis and multifaceted pharmacological activity of novel quinazoline NHE-1 inhibitors

Synthesis and multifaceted pharmacological activity of novel quinazoline NHE-1 inhibitors

Abstract The Na+/H+ exchanger isoform 1 (NHE-1) attracts ongoing attention as a validated drug target for the management of cardiovascular and ocular diseases owing to cytoprotective, anti-ischemic and anti-inflammatory properties of NHE-1 inhibitors. Herein we report novel NHE-1 inhibitors realized...

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Bibliographic Details
Main Authors: Alexander Spasov, Alexander Ozerov, Pavel Vassiliev, Vadim Kosolapov, Natalia Gurova, Aida Kucheryavenko, Ludmila Naumenko, Denis Babkov, Viktor Sirotenko, Alena Taran, Roman Litvinov, Alexander Borisov, Vladlen Klochkov, Darya Merezhkina, Mikhail Miroshnikov, Georgy Uskov, Nadezhda Ovsyankina
Format: Article
Language:English
Published: Nature Portfolio 2021-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-03722-w

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https://doi.org/10.1038/s41598-021-03722-w

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