Mesenchymal Stem Cells Modified with Heme Oxygenase-1 Have Enhanced Paracrine Function and Attenuate Lipopolysaccharide-Induced Inflammatory and Oxidative Damage in Pulmonary Microvascular Endothelial Cells

Mesenchymal Stem Cells Modified with Heme Oxygenase-1 Have Enhanced Paracrine Function and Attenuate Lipopolysaccharide-Induced Inflammatory and Oxidative Damage in Pulmonary Microvascular Endothelial Cells

Background/Aims: Bone marrow-derived mesenchymal stem cell (BM-MSC) transplantation has therapeutic effects on endothelial damage during acute lung injury (ALI). Heme oxygenase-1 (HO-1) can restore homeostasis and implement cytoprotective defense functions in many pathologic states. Therefore, we ex...

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Bibliographic Details
Main Authors: Xuxin Chen, Yinliang Zhang, Wenjing Wang, Zhenqian Liu, Jiguang  Meng, Zhihai Han
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
Mesenchymal Stem Cells (MSCs)
Acute lung injury (ALI)
Lipopolysaccharide (LPS)
Heme Oxygenase-1 (HO-1)
Paracrine
Inflammation
Oxidative Stress
Online Access:https://www.karger.com/Article/FullText/492847

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https://www.karger.com/Article/FullText/492847

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