Developmental molecular and functional cerebellar alterations induced by PCP4/PEP19 overexpression: Implications for Down syndrome

Developmental molecular and functional cerebellar alterations induced by PCP4/PEP19 overexpression: Implications for Down syndrome

PCP4/PEP19 is a modulator of Ca2+-CaM signaling. In the brain, it is expressed in a very specific pattern in postmitotic neurons. In particular, Pcp4 is highly expressed in the Purkinje cell, the sole output neuron of the cerebellum. PCP4, located on human chromosome 21, is present in three copies i...

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Bibliographic Details
Main Authors: François Mouton-Liger, Ignasi Sahún, Thibault Collin, Patricia Lopes Pereira, Debora Masini, Sophie Thomas, Evelyne Paly, Sabrina Luilier, Sandra Même, Quentin Jouhault, Soumia Bennaï, Jean-Claude Beloeil, Jean-Charles Bizot, Yann Hérault, Mara Dierssen, Nicole Créau
Format: Article
Language:English
Published: Elsevier 2014-03-01
Series:Neurobiology of Disease
Subjects:
Pcp4
Transgenic mouse
Down syndrome
Cerebellum
Learning
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611300329X

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http://www.sciencedirect.com/science/article/pii/S096999611300329X

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