Generation of a human induced pluripotent stem cell line overexpressing CCL22 with islet cells differentiation potential
CCL22 is a macrophage-derived immunosuppressive chemokine that recruits regulatory T cells through the CCL22:CCR4 axis, playing an important role in homeostatic and inflammatory responses. A CCL22-overexpressing human induced pluripotent stem cell line (CNNDi001-A-2) was generated by lentiviral tran...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S187350612300288X |
| _version_ | 1797319498488872960 |
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| author | Duan Jinliang Bai Fang Zhu Xiaofeng He Xiaoshun Hu Anbin |
| author_facet | Duan Jinliang Bai Fang Zhu Xiaofeng He Xiaoshun Hu Anbin |
| author_sort | Duan Jinliang |
| collection | DOAJ |
| description | CCL22 is a macrophage-derived immunosuppressive chemokine that recruits regulatory T cells through the CCL22:CCR4 axis, playing an important role in homeostatic and inflammatory responses. A CCL22-overexpressing human induced pluripotent stem cell line (CNNDi001-A-2) was generated by lentiviral transduction to further study the function of CCL22. The cell line was confirmed to have normal proliferation and pluripotency and could be further differentiated into islet cells for cell replacement therapy in diabetes. |
| first_indexed | 2024-03-08T04:07:45Z |
| format | Article |
| id | doaj.art-95d711c5d17b4a738d28f059771e6712 |
| institution | Directory Open Access Journal |
| issn | 1873-5061 |
| language | English |
| last_indexed | 2024-03-08T04:07:45Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj.art-95d711c5d17b4a738d28f059771e67122024-02-09T04:47:54ZengElsevierStem Cell Research1873-50612024-03-0175103302Generation of a human induced pluripotent stem cell line overexpressing CCL22 with islet cells differentiation potentialDuan Jinliang0Bai Fang1Zhu Xiaofeng2He Xiaoshun3Hu Anbin4Organ Transplantation Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong,China; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial International Cooperation Base of Science and Technology(Organ Transplantation), Guangzhou, Guangdong, ChinaOrgan Transplantation Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong,China; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial International Cooperation Base of Science and Technology(Organ Transplantation), Guangzhou, Guangdong, ChinaOrgan Transplantation Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong,China; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial International Cooperation Base of Science and Technology(Organ Transplantation), Guangzhou, Guangdong, ChinaOrgan Transplantation Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong,China; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial International Cooperation Base of Science and Technology(Organ Transplantation), Guangzhou, Guangdong, ChinaOrgan Transplantation Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong,China; Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial International Cooperation Base of Science and Technology(Organ Transplantation), Guangzhou, Guangdong, China; Corresponding author.CCL22 is a macrophage-derived immunosuppressive chemokine that recruits regulatory T cells through the CCL22:CCR4 axis, playing an important role in homeostatic and inflammatory responses. A CCL22-overexpressing human induced pluripotent stem cell line (CNNDi001-A-2) was generated by lentiviral transduction to further study the function of CCL22. The cell line was confirmed to have normal proliferation and pluripotency and could be further differentiated into islet cells for cell replacement therapy in diabetes.http://www.sciencedirect.com/science/article/pii/S187350612300288X |
| spellingShingle | Duan Jinliang Bai Fang Zhu Xiaofeng He Xiaoshun Hu Anbin Generation of a human induced pluripotent stem cell line overexpressing CCL22 with islet cells differentiation potential Stem Cell Research |
| title | Generation of a human induced pluripotent stem cell line overexpressing CCL22 with islet cells differentiation potential |
| title_full | Generation of a human induced pluripotent stem cell line overexpressing CCL22 with islet cells differentiation potential |
| title_fullStr | Generation of a human induced pluripotent stem cell line overexpressing CCL22 with islet cells differentiation potential |
| title_full_unstemmed | Generation of a human induced pluripotent stem cell line overexpressing CCL22 with islet cells differentiation potential |
| title_short | Generation of a human induced pluripotent stem cell line overexpressing CCL22 with islet cells differentiation potential |
| title_sort | generation of a human induced pluripotent stem cell line overexpressing ccl22 with islet cells differentiation potential |
| url | http://www.sciencedirect.com/science/article/pii/S187350612300288X |
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