Clusterin-carrying extracellular vesicles derived from human umbilical cord mesenchymal stem cells restore the ovarian function of premature ovarian failure mice through activating the PI3K/AKT pathway

Clusterin-carrying extracellular vesicles derived from human umbilical cord mesenchymal stem cells restore the ovarian function of premature ovarian failure mice through activating the PI3K/AKT pathway

Abstract Background Emerging evidence has highlighted the therapeutic potential of human umbilical cord mesenchymal stem cells (UC-MSCs) in chemotherapy-induced premature ovarian failure (POF). This study was designed to investigate the appropriate timing and molecular mechanism of UC-MSCs treatment...

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Bibliographic Details
Main Authors: Jing He, Chunchun Ao, Mao Li, Taoran Deng, Shuo Zheng, Ke Zhang, Chengshu Tu, Yu Ouyang, Ruibo Lang, Yijia Jiang, Yifan Yang, Changyong Li, Dongcheng Wu
Format: Article
Language:English
Published: BMC 2024-09-01
Series:Stem Cell Research & Therapy
Subjects:
POF
UC-MSCs
EVs
Clusterin
PI3K/AKT
Online Access:https://doi.org/10.1186/s13287-024-03926-7

Internet

https://doi.org/10.1186/s13287-024-03926-7

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