Evaluation of the mTORC activity in the presence of Toxoplasma gondii and azathioprine in human monocyte cell line

Evaluation of the mTORC activity in the presence of Toxoplasma gondii and azathioprine in human monocyte cell line

Abstract Background Autophagy is an important part of pathogenesis of IBD. Thiopurines such as azathioprine (AZA) are approved drugs for clinical practices in IBD patients. Besides, as an escape strategy, Toxoplasma gondii can use the mTORC1 complex to inactivate autophagy. Methods In this study, we...

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Bibliographic Details
Main Authors: Sara Nemati, Hanieh Mohammad Rahimi, Anna Meyfour, Hossein Pazoki, Hamid Asadzadeh Aghdaei, Shabnam Shahrokh, Hamed Mirjalali
Format: Article
Language:English
Published: BMC 2023-03-01
Series:BMC Microbiology
Subjects:
Toxoplasma gondii
Autophagy
mTORC
Azathioprine
Inflammatory Bowel Diseases
Online Access:https://doi.org/10.1186/s12866-023-02819-8

Internet

https://doi.org/10.1186/s12866-023-02819-8

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