Alpha 1 Antitrypsin-Deficient Macrophages Have Impaired Efferocytosis of Apoptotic Neutrophils

Alpha 1 Antitrypsin-Deficient Macrophages Have Impaired Efferocytosis of Apoptotic Neutrophils

Alpha 1 antitrypsin deficiency (AATD) is an autosomal co-dominant disorder characterized by a low level of circulating AAT, which significantly reduces protection for the lower airways against proteolytic burden caused by neutrophils. Neutrophils, which are terminally differentiated innate immune ce...

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Bibliographic Details
Main Authors: Jungnam Lee, Yuanqing Lu, Regina Oshins, Jesse West, Craig G. Moneypenny, Kyudong Han, Mark L. Brantly
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
Alpha 1 antitrysin
AAT deficiency
neutrophil
macrophage
efferocytosis
cytokine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.574410/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.574410/full

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