Genome-wide quantification of the effects of DNA methylation on human gene regulation

Genome-wide quantification of the effects of DNA methylation on human gene regulation

Changes in DNA methylation are involved in development, disease, and the response to environmental conditions. However, not all regulatory elements are functionally methylation-dependent (MD). Here, we report a method, mSTARR-seq, that assesses the causal effects of DNA methylation on regulatory act...

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Bibliographic Details
Main Authors: Amanda J Lea, Christopher M Vockley, Rachel A Johnston, Christina A Del Carpio, Luis B Barreiro, Timothy E Reddy, Jenny Tung
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-12-01
Series:eLife
Subjects:
DNA methylation
epigenomics
high-throughput reporter assay
Online Access:https://elifesciences.org/articles/37513

Internet

https://elifesciences.org/articles/37513

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