Downregulation of leptin inhibits growth and induces apoptosis of lung cancer cells via the Notch and JAK/STAT3 signaling pathways

Downregulation of leptin inhibits growth and induces apoptosis of lung cancer cells via the Notch and JAK/STAT3 signaling pathways

Previous studies have documented that leptin is involved in the pathogenesis of many human cancer types by regulation of numerous signal transduction pathways. The aim of this study was to investigate the biological roles of leptin and the mechanisms attributed to its action in non-small cell lung c...

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Bibliographic Details
Main Authors: Xian-Jie Zheng, Zhong-Xin Yang, Yan-Jun Dong, Guo-Yu Zhang, Ming-Fei Sun, Xiao-Kang An, Li-Hong Pan, Shuang-Lin Zhang
Format: Article
Language:English
Published: The Company of Biologists 2016-06-01
Series:Biology Open
Subjects:
Leptin
Non-small cell lung cancer
Proliferation
Apoptosis
Notch
JAK/STAT3
Online Access:http://bio.biologists.org/content/5/6/794

Internet

http://bio.biologists.org/content/5/6/794

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