MicroRNAs and Ascl1 facilitate direct conversion of porcine fibroblasts into induced neurons

MicroRNAs and Ascl1 facilitate direct conversion of porcine fibroblasts into induced neurons

Direct neuronal conversion describes the process of generating induced neurons from somatic cells such as fibroblasts by overexpressing cell type-specific transcription factors, microRNAs or by culturing in the presence of small molecules. This was first achieved by expressing Brn2, Ascl1 and Myt1L...

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Bibliographic Details
Main Authors: Mette Habekost, Arne Lund Jørgensen, Per Qvist, Mark Denham
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Stem Cell Research
Subjects:
Disease modelling
Porcine induced neurons
Direct reprogramming
Neuronal conversion
Regenerative medicine
MicroRNA
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506120302853

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http://www.sciencedirect.com/science/article/pii/S1873506120302853

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