The emerging role and targetability of the TCA cycle in cancer metabolism

The emerging role and targetability of the TCA cycle in cancer metabolism

ABSTRACT The tricarboxylic acid (TCA) cycle is a central route for oxidative phosphorylation in cells, and fulfills their bioenergetic, biosynthetic, and redox balance requirements. Despite early dogma that cancer cells bypass the TCA cycle and primarily utilize aerobic glycolysis, emerging evidence...

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Bibliographic Details
Main Authors: Nicole M. Anderson, Patrick Mucka, Joseph G. Kern, Hui Feng
Format: Article
Language:English
Published: Oxford University Press 2017-07-01
Series:Protein & Cell
Subjects:
glutaminolysis
the TCA cycle
cancer metabolism
glycolysis
Online Access:http://link.springer.com/article/10.1007/s13238-017-0451-1

Internet

http://link.springer.com/article/10.1007/s13238-017-0451-1

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