Lupus Nephritis: Enigmas, Conflicting Models and an Emerging Concept

Lupus Nephritis: Enigmas, Conflicting Models and an Emerging Concept

Abstract Autoantibodies to components of chromatin, which include double-stranded DNA (dsDNA), histones and nucleosomes, are central in the pathogenesis of lupus nephritis. How anti-chromatin autoantibodies exert their nephritogenic activity, however, is controversial. One model assumes that autoant...

Full description

Bibliographic Details
Main Authors: Natalya Seredkina, Johan van der Vlag, Jo Berden, Elin Mortensen, Ole Petter Rekvig
Format: Article
Language:English
Published: BMC 2013-06-01
Series:Molecular Medicine
Subjects:
Lupus Nephritis
Nephritic Kidneys
DNasel
Chromatin Fragmentation
anti-dsDNA Antibodies
Online Access:https://doi.org/10.2119/molmed.2013.00010

Similar Items

Similar Items