The Cytosolic Phospholipase A<sub>2</sub>α N-Terminal C2 Domain Binds and Oligomerizes on Membranes with Positive Curvature

The Cytosolic Phospholipase A<sub>2</sub>α N-Terminal C2 Domain Binds and Oligomerizes on Membranes with Positive Curvature

Group IV phospholipase A<sub>2</sub>α (cPLA<sub>2</sub>α) regulates the production of prostaglandins and leukotrienes via the formation of arachidonic acid from membrane phospholipids. The targeting and membrane binding of cPLA<sub>2</sub>α to the Golgi involves t...

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Bibliographic Details
Main Authors: Katherine E. Ward, Ranjan Sengupta, James P. Ropa, Souad Amiar, Robert V. Stahelin
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Biomolecules
Subjects:
cytosolic phospholipase A<sub>2</sub>α (cPLA<sub>2</sub>α)
electron microscopy
Golgi
membrane bending
membrane curvature
C2 domain
Online Access:https://www.mdpi.com/2218-273X/10/4/647

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https://www.mdpi.com/2218-273X/10/4/647

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