Inhibition of oxidative stress and advanced glycation end‐product formation in purified BSA/glucose glycation system by polyphenol extracts of selected nuts from Pakistan
Abstract Glycation generates advanced glycation end products (AGE) and its intermediates, thus increasing the risk of developing various ailments including diabetes mellitus. Current study was planned to explore the antioxidant and antiglycation potential of selected nuts viz, Juglans regia (Walnut)...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-06-01
|
| Series: | Food Science & Nutrition |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/fsn3.3331 |
| _version_ | 1797805706516103168 |
|---|---|
| author | Asia Atta Muhammad Shahid Zunaira Kanwal Saghir Ahmad Jafri Muhammad Riaz Hang Xiao Mazhar Abbas Chukwuebuka Egbuna Jesus Simal‐Gandara |
| author_facet | Asia Atta Muhammad Shahid Zunaira Kanwal Saghir Ahmad Jafri Muhammad Riaz Hang Xiao Mazhar Abbas Chukwuebuka Egbuna Jesus Simal‐Gandara |
| author_sort | Asia Atta |
| collection | DOAJ |
| description | Abstract Glycation generates advanced glycation end products (AGE) and its intermediates, thus increasing the risk of developing various ailments including diabetes mellitus. Current study was planned to explore the antioxidant and antiglycation potential of selected nuts viz, Juglans regia (Walnut), Prunus dulcis (Almond), Pistacia vera (Pistachio), and Arachis hypogaea (Peanut), locally available and readily consumed in Faisalabad, Pakistan, for their health‐promoting properties. The prepared methanolic extracts of selected nuts were tested for biological activities including the antioxidant and antiglycation potential. The effect of these extracts against oxidation and AGE formation was evaluated by in vitro method using bovine serum albumin (BSA)‐glucose system. Juglans regia, Pistacia vera, and Arachis hypogaea were found rich in phenolics and flavonoids contents with increased reducing potential and least IC50 due to the DPPH free radical scavenging inhibition. Dose‐ and time‐dependent inhibition of glucose‐induced advanced glycation end‐product (AGE) was exhibited by fruit extracts through in vitro bovine serum albumin (BSA)‐glucose system. Juglans regia and Pistacia vera were predominantly effective in the inhibition of early and intermediary glycation products at different incubation conditions. The study indicated that the extracts of selected nuts possess significant antioxidant capacity and are rich in phenolics and flavonoids, making them useful supplements as an important part of a balanced diet. |
| first_indexed | 2024-03-13T05:56:08Z |
| format | Article |
| id | doaj.art-95f6a38e18074ef6a3c7b65d95de867b |
| institution | Directory Open Access Journal |
| issn | 2048-7177 |
| language | English |
| last_indexed | 2024-03-13T05:56:08Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Food Science & Nutrition |
| spelling | doaj.art-95f6a38e18074ef6a3c7b65d95de867b2023-06-13T05:10:23ZengWileyFood Science & Nutrition2048-71772023-06-011163414342110.1002/fsn3.3331Inhibition of oxidative stress and advanced glycation end‐product formation in purified BSA/glucose glycation system by polyphenol extracts of selected nuts from PakistanAsia Atta0Muhammad Shahid1Zunaira Kanwal2Saghir Ahmad Jafri3Muhammad Riaz4Hang Xiao5Mazhar Abbas6Chukwuebuka Egbuna7Jesus Simal‐Gandara8Department of Biochemistry NUR International University Lahore 54000 PakistanDepartment of Biochemistry University of Agriculture Faisalabad 38040 PakistanDepartment of Biochemistry Allama Iqbal Medical College Lahore 54000 PakistanDean Faculty of Sciences NUR International University Lahore 54000 PakistanDepartment of Allied Health Sciences University of Sargodha Sargodha 40100 PakistanDepartment of Food Science University of Massachusetts Amherst 100 Holdsworth Way Amherst Massachusetts 01003 USADepartment of Basic Sciences (Section Biochemistry) University of Veterinary and Animal Sciences Jhang Campus Lahore 35200 PakistanAfrica Centre of Excellence, Centre for Public Health and Toxicological Research (ACE‐PUTOR) University of Port‐Harcourt Port‐Harcourt NigeriaNutrition and Bromatology Group, Analytical Chemistry and Food Science Department, Faculty of Science Universidade de Vigo E‐32004 Ourense SpainAbstract Glycation generates advanced glycation end products (AGE) and its intermediates, thus increasing the risk of developing various ailments including diabetes mellitus. Current study was planned to explore the antioxidant and antiglycation potential of selected nuts viz, Juglans regia (Walnut), Prunus dulcis (Almond), Pistacia vera (Pistachio), and Arachis hypogaea (Peanut), locally available and readily consumed in Faisalabad, Pakistan, for their health‐promoting properties. The prepared methanolic extracts of selected nuts were tested for biological activities including the antioxidant and antiglycation potential. The effect of these extracts against oxidation and AGE formation was evaluated by in vitro method using bovine serum albumin (BSA)‐glucose system. Juglans regia, Pistacia vera, and Arachis hypogaea were found rich in phenolics and flavonoids contents with increased reducing potential and least IC50 due to the DPPH free radical scavenging inhibition. Dose‐ and time‐dependent inhibition of glucose‐induced advanced glycation end‐product (AGE) was exhibited by fruit extracts through in vitro bovine serum albumin (BSA)‐glucose system. Juglans regia and Pistacia vera were predominantly effective in the inhibition of early and intermediary glycation products at different incubation conditions. The study indicated that the extracts of selected nuts possess significant antioxidant capacity and are rich in phenolics and flavonoids, making them useful supplements as an important part of a balanced diet.https://doi.org/10.1002/fsn3.3331antiglycationantioxidantsfree radicalshyperglycemiapolyphenols |
| spellingShingle | Asia Atta Muhammad Shahid Zunaira Kanwal Saghir Ahmad Jafri Muhammad Riaz Hang Xiao Mazhar Abbas Chukwuebuka Egbuna Jesus Simal‐Gandara Inhibition of oxidative stress and advanced glycation end‐product formation in purified BSA/glucose glycation system by polyphenol extracts of selected nuts from Pakistan Food Science & Nutrition antiglycation antioxidants free radicals hyperglycemia polyphenols |
| title | Inhibition of oxidative stress and advanced glycation end‐product formation in purified BSA/glucose glycation system by polyphenol extracts of selected nuts from Pakistan |
| title_full | Inhibition of oxidative stress and advanced glycation end‐product formation in purified BSA/glucose glycation system by polyphenol extracts of selected nuts from Pakistan |
| title_fullStr | Inhibition of oxidative stress and advanced glycation end‐product formation in purified BSA/glucose glycation system by polyphenol extracts of selected nuts from Pakistan |
| title_full_unstemmed | Inhibition of oxidative stress and advanced glycation end‐product formation in purified BSA/glucose glycation system by polyphenol extracts of selected nuts from Pakistan |
| title_short | Inhibition of oxidative stress and advanced glycation end‐product formation in purified BSA/glucose glycation system by polyphenol extracts of selected nuts from Pakistan |
| title_sort | inhibition of oxidative stress and advanced glycation end product formation in purified bsa glucose glycation system by polyphenol extracts of selected nuts from pakistan |
| topic | antiglycation antioxidants free radicals hyperglycemia polyphenols |
| url | https://doi.org/10.1002/fsn3.3331 |
| work_keys_str_mv | AT asiaatta inhibitionofoxidativestressandadvancedglycationendproductformationinpurifiedbsaglucoseglycationsystembypolyphenolextractsofselectednutsfrompakistan AT muhammadshahid inhibitionofoxidativestressandadvancedglycationendproductformationinpurifiedbsaglucoseglycationsystembypolyphenolextractsofselectednutsfrompakistan AT zunairakanwal inhibitionofoxidativestressandadvancedglycationendproductformationinpurifiedbsaglucoseglycationsystembypolyphenolextractsofselectednutsfrompakistan AT saghirahmadjafri inhibitionofoxidativestressandadvancedglycationendproductformationinpurifiedbsaglucoseglycationsystembypolyphenolextractsofselectednutsfrompakistan AT muhammadriaz inhibitionofoxidativestressandadvancedglycationendproductformationinpurifiedbsaglucoseglycationsystembypolyphenolextractsofselectednutsfrompakistan AT hangxiao inhibitionofoxidativestressandadvancedglycationendproductformationinpurifiedbsaglucoseglycationsystembypolyphenolextractsofselectednutsfrompakistan AT mazharabbas inhibitionofoxidativestressandadvancedglycationendproductformationinpurifiedbsaglucoseglycationsystembypolyphenolextractsofselectednutsfrompakistan AT chukwuebukaegbuna inhibitionofoxidativestressandadvancedglycationendproductformationinpurifiedbsaglucoseglycationsystembypolyphenolextractsofselectednutsfrompakistan AT jesussimalgandara inhibitionofoxidativestressandadvancedglycationendproductformationinpurifiedbsaglucoseglycationsystembypolyphenolextractsofselectednutsfrompakistan |