Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics

Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics

Recent studies have indicated that the serotonin receptor subtype 7 (5-HT7R) plays a crucial role in shaping neuronal morphology during embryonic and early postnatal life. Here we show that pharmacological stimulation of 5-HT7R using a highly selective agonist, LP-211, enhances neurite outgrowth in...

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Bibliographic Details
Main Authors: Luisa eSperanza, Teresa eGiuliano, Floriana eVolpicelli, Maria Egle eDe Stefano, Loredana eLombardi, Angela eChambery, Enza eLacivita, Marcello eLeopoldo, Gian Carlo eBellenchi, Umberto edi Porzio, Marianna eCrispino, Carla ePerrone-Capano
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Cdc42
actin dynamics
mTOR
Neurite outgrowth
Axonal elongation
5-HT7 receptor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00062/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00062/full

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