Synergistic Effects of Adenosine A2A Antagonist and L-DOPA on Rotational Behaviors in 6-Hydroxydopamine-Induced Hemi-Parkinsonian Mouse Model

Synergistic Effects of Adenosine A2A Antagonist and L-DOPA on Rotational Behaviors in 6-Hydroxydopamine-Induced Hemi-Parkinsonian Mouse Model

In this study, we examined the combination effects of L-DOPA and adenosine receptor antagonists on rotational behaviors in a hemi-Parkinsonian mouse model induced by unilateral 6-hydroxydopamine (6-OHDA) injection. The adenosine A2A antagonist SCH-58261, but not the A1-receptor antagonist 8-cyclopen...

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Main Authors: Takahiro Matsuya, Kazuhiro Takuma, Kosuke Sato, Makoto Asai, Yoshihiro Murakami, Sosuke Miyoshi, Akihiro Noda, Taku Nagai, Hiroyuki Mizoguchi, Shintaro Nishimura, Kiyofumi Yamada
Format: Article
Language:English
Published: Elsevier 2007-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319343129

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http://www.sciencedirect.com/science/article/pii/S1347861319343129

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