Synergistic Effects of Adenosine A2A Antagonist and L-DOPA on Rotational Behaviors in 6-Hydroxydopamine-Induced Hemi-Parkinsonian Mouse Model
In this study, we examined the combination effects of L-DOPA and adenosine receptor antagonists on rotational behaviors in a hemi-Parkinsonian mouse model induced by unilateral 6-hydroxydopamine (6-OHDA) injection. The adenosine A2A antagonist SCH-58261, but not the A1-receptor antagonist 8-cyclopen...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2007-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319343129 |
| _version_ | 1811287254987964416 |
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| author | Takahiro Matsuya Kazuhiro Takuma Kosuke Sato Makoto Asai Yoshihiro Murakami Sosuke Miyoshi Akihiro Noda Taku Nagai Hiroyuki Mizoguchi Shintaro Nishimura Kiyofumi Yamada |
| author_facet | Takahiro Matsuya Kazuhiro Takuma Kosuke Sato Makoto Asai Yoshihiro Murakami Sosuke Miyoshi Akihiro Noda Taku Nagai Hiroyuki Mizoguchi Shintaro Nishimura Kiyofumi Yamada |
| author_sort | Takahiro Matsuya |
| collection | DOAJ |
| description | In this study, we examined the combination effects of L-DOPA and adenosine receptor antagonists on rotational behaviors in a hemi-Parkinsonian mouse model induced by unilateral 6-hydroxydopamine (6-OHDA) injection. The adenosine A2A antagonist SCH-58261, but not the A1-receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine or A2B-receptor antagonist alloxazine, synergistically potentiated the L-DOPA-induced rotational behaviors in the 6-OHDA-lesioned mice. In addtion, the 6-OHDA-induced lesions of the dopaminergic system did not affect the in vivo binding of an adenosine A2A-receptor tracer [11C]SCH-442416 in the striatatum. These findings suggest that adenosine A2A antagonists are extremely useful for pharmacotherapy of L-DOPA in Parkinson’s disease patients. Keywords:: adenosine A2A receptor, L-DOPA, hemi-Parkinsonian mouse model |
| first_indexed | 2024-04-13T03:14:19Z |
| format | Article |
| id | doaj.art-9602c4f86f7a4a118e552dae448f0565 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-04-13T03:14:19Z |
| publishDate | 2007-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-9602c4f86f7a4a118e552dae448f05652022-12-22T03:04:57ZengElsevierJournal of Pharmacological Sciences1347-86132007-01-011033329332Synergistic Effects of Adenosine A2A Antagonist and L-DOPA on Rotational Behaviors in 6-Hydroxydopamine-Induced Hemi-Parkinsonian Mouse ModelTakahiro Matsuya0Kazuhiro Takuma1Kosuke Sato2Makoto Asai3Yoshihiro Murakami4Sosuke Miyoshi5Akihiro Noda6Taku Nagai7Hiroyuki Mizoguchi8Shintaro Nishimura9Kiyofumi Yamada10Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920-1192, Japan; Basic Research Division, The Medical and Pharmacological Research Center Foundation, Ishikawa 925-0613, JapanLaboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920-1192, JapanLaboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920-1192, JapanBasic Research Division, The Medical and Pharmacological Research Center Foundation, Ishikawa 925-0613, JapanBasic Research Division, The Medical and Pharmacological Research Center Foundation, Ishikawa 925-0613, JapanBasic Research Division, The Medical and Pharmacological Research Center Foundation, Ishikawa 925-0613, JapanBasic Research Division, The Medical and Pharmacological Research Center Foundation, Ishikawa 925-0613, JapanLaboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920-1192, JapanLaboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920-1192, JapanBasic Research Division, The Medical and Pharmacological Research Center Foundation, Ishikawa 925-0613, JapanLaboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920-1192, Japan; Corresponding author. kyamada@p.kanazawa-u.ac.jpIn this study, we examined the combination effects of L-DOPA and adenosine receptor antagonists on rotational behaviors in a hemi-Parkinsonian mouse model induced by unilateral 6-hydroxydopamine (6-OHDA) injection. The adenosine A2A antagonist SCH-58261, but not the A1-receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine or A2B-receptor antagonist alloxazine, synergistically potentiated the L-DOPA-induced rotational behaviors in the 6-OHDA-lesioned mice. In addtion, the 6-OHDA-induced lesions of the dopaminergic system did not affect the in vivo binding of an adenosine A2A-receptor tracer [11C]SCH-442416 in the striatatum. These findings suggest that adenosine A2A antagonists are extremely useful for pharmacotherapy of L-DOPA in Parkinson’s disease patients. Keywords:: adenosine A2A receptor, L-DOPA, hemi-Parkinsonian mouse modelhttp://www.sciencedirect.com/science/article/pii/S1347861319343129 |
| spellingShingle | Takahiro Matsuya Kazuhiro Takuma Kosuke Sato Makoto Asai Yoshihiro Murakami Sosuke Miyoshi Akihiro Noda Taku Nagai Hiroyuki Mizoguchi Shintaro Nishimura Kiyofumi Yamada Synergistic Effects of Adenosine A2A Antagonist and L-DOPA on Rotational Behaviors in 6-Hydroxydopamine-Induced Hemi-Parkinsonian Mouse Model Journal of Pharmacological Sciences |
| title | Synergistic Effects of Adenosine A2A Antagonist and L-DOPA on Rotational Behaviors in 6-Hydroxydopamine-Induced Hemi-Parkinsonian Mouse Model |
| title_full | Synergistic Effects of Adenosine A2A Antagonist and L-DOPA on Rotational Behaviors in 6-Hydroxydopamine-Induced Hemi-Parkinsonian Mouse Model |
| title_fullStr | Synergistic Effects of Adenosine A2A Antagonist and L-DOPA on Rotational Behaviors in 6-Hydroxydopamine-Induced Hemi-Parkinsonian Mouse Model |
| title_full_unstemmed | Synergistic Effects of Adenosine A2A Antagonist and L-DOPA on Rotational Behaviors in 6-Hydroxydopamine-Induced Hemi-Parkinsonian Mouse Model |
| title_short | Synergistic Effects of Adenosine A2A Antagonist and L-DOPA on Rotational Behaviors in 6-Hydroxydopamine-Induced Hemi-Parkinsonian Mouse Model |
| title_sort | synergistic effects of adenosine a2a antagonist and l dopa on rotational behaviors in 6 hydroxydopamine induced hemi parkinsonian mouse model |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319343129 |
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