Partial loss of MCU mitigates pathology in vivo across a diverse range of neurodegenerative disease models

Partial loss of MCU mitigates pathology in vivo across a diverse range of neurodegenerative disease models

Summary: Mitochondrial calcium (Ca2+) uptake augments metabolic processes and buffers cytosolic Ca2+ levels; however, excessive mitochondrial Ca2+ can cause cell death. Disrupted mitochondrial function and Ca2+ homeostasis are linked to numerous neurodegenerative diseases (NDs), but the impact of mi...

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Bibliographic Details
Main Authors: Madeleine J. Twyning, Roberta Tufi, Thomas P. Gleeson, Kinga M. Kolodziej, Susanna Campesan, Ana Terriente-Felix, Lewis Collins, Federica De Lazzari, Flaviano Giorgini, Alexander J. Whitworth
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Cell Reports
Subjects:
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724000093

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http://www.sciencedirect.com/science/article/pii/S2211124724000093

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