The DEG/ENaC cation channel protein UNC-8 drives activity-dependent synapse removal in remodeling GABAergic neurons

The DEG/ENaC cation channel protein UNC-8 drives activity-dependent synapse removal in remodeling GABAergic neurons

Genetic programming and neural activity drive synaptic remodeling in developing neural circuits, but the molecular components that link these pathways are poorly understood. Here we show that the C. elegans Degenerin/Epithelial Sodium Channel (DEG/ENaC) protein, UNC-8, is transcriptionally controlle...

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Bibliographic Details
Main Authors: Tyne W Miller-Fleming, Sarah C Petersen, Laura Manning, Cristina Matthewman, Megan Gornet, Allison Beers, Sayaka Hori, Shohei Mitani, Laura Bianchi, Janet Richmond, David M Miller III
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-07-01
Series:eLife
Subjects:
synaptic remodeling
calcium signaling
cation channel
Online Access:https://elifesciences.org/articles/14599

Internet

https://elifesciences.org/articles/14599

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