Immune landscape and the key role of APOE+ monocytes of lupus nephritis under the single‐cell and spatial transcriptional vista

Immune landscape and the key role of APOE+ monocytes of lupus nephritis under the single‐cell and spatial transcriptional vista

Abstract Background Lupus nephritis (LN) is among the most common complication of systemic lupus erythematosus (SLE) with high mortality and morbidity. The analysis of LN kidney's local immune response through single‐cell and spatial transcriptome enables the study of potential therapeutic targ...

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Bibliographic Details
Main Authors: Youzhou Tang, Ying Zhang, Xinyu Li, Ruoyao Xu, Ying Ji, Jishi Liu, Jianye Liu, Quan Zhuang, Hao Zhang
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Clinical and Translational Medicine
Subjects:
APOE
immune landscape
lupus nephritis
single‐cell transcriptomic sequencing
spatial transcriptome
Online Access:https://doi.org/10.1002/ctm2.1237

Internet

https://doi.org/10.1002/ctm2.1237

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