MSC-Derived Small Extracellular Vesicles Attenuate Autoimmune Dacryoadenitis by Promoting M2 Macrophage Polarization and Inducing Tregs via miR-100-5p

MSC-Derived Small Extracellular Vesicles Attenuate Autoimmune Dacryoadenitis by Promoting M2 Macrophage Polarization and Inducing Tregs via miR-100-5p

BackgroundMesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) have been increasingly proved as promising immunomodulators against some autoimmune disorders. However, the possible effect and the underlying mechanism of MSC-sEVs in autoimmune dry eye have been rarely studied.MethodsS...

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Bibliographic Details
Main Authors: Na Li, Zhiqi Gao, Lu Zhao, Bei Du, Binyun Ma, Hong Nian, Ruihua Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
small extracellular vesicles
human umbilical cord mesenchymal stem cells
autoimmune dacryoadenitis
tregs
macrophages
miR-100-5p
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.888949/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.888949/full

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