Indium-Mediated Reformatsky Reaction of Iododifluoro Ketones with Aldehydes: Preparation of α,α-Difluoro-β-hydroxyketone Derivatives in Water

Indium-Mediated Reformatsky Reaction of Iododifluoro Ketones with Aldehydes: Preparation of α,α-Difluoro-β-hydroxyketone Derivatives in Water

Indium can efficiently mediate the Reformatsky reaction of iododifluoroacetylketones with aldehydes to afford the corresponding α,α-difluoro-β-hydroxyketones in high yield in pure water This reaction has excellent substrate suitability and functional group selectivity and provides an efficient appro...

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Bibliographic Details
Main Authors: Zhongyuan Li, Jinwen Huang, Zhuang Ni, Ran Sun, Hui Nie, Hui Tang, Lixing Song, Fanhong Wu
Format: Article
Language:English
Published: Georg Thieme Verlag KG 2022-01-01
Series:SynOpen
Subjects:
indium
reformatsky reaction
α-iodo-α,α-difluoroketone
α,α-difluoro-β-hydroxyketone
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1719888

Internet

http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1719888

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