Investigation of the relationship between ergocristinine and vascular receptors

Ergot alkaloids are secondary metabolites that exist in two configurations, the C-8-R-isomer (R-epimer), and the C-8-S-isomer (S-epimer). Toxic effects of ergot, such as vasoconstriction, have been primarily attributed to the R-epimer bioactivity, as compared to the S-epimer. Recent studies demonstr...

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Bibliographic Details
Main Authors: Jensen E. Cherewyk, Barry R. Blakley, Ahmad N. Al-Dissi
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Toxicology Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750023000586