Intranasal cerium oxide nanoparticles improves locomotor activity and reduces oxidative stress and neuroinflammation in haloperidol-induced parkinsonism in rats

Intranasal cerium oxide nanoparticles improves locomotor activity and reduces oxidative stress and neuroinflammation in haloperidol-induced parkinsonism in rats

Introduction: Cerium oxide nanoparticles (CONPs) have been investigated for their therapeutic potential in Parkinson’s disease (PD) due to their potent and regenerative antioxidant activity. In the present study, CONPs were used to ameliorate the oxidative stress caused by free radicals in haloperid...

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Bibliographic Details
Main Authors: Mohammad, Urooj Ahmed Khan, Musarrat Husain Warsi, Huda Mohammed Alkreathy, Shahid Karim, Gaurav Kumar Jain, Asgar Ali
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Pharmacology
Subjects:
Parkinson disease
brain targeting
antioxidant activity
gamma scintigraphy
inorganic nanoparticles
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1188470/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1188470/full

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