Bacterial and metabolic phenotypes associated with inadequate response to ursodeoxycholic acid treatment in primary biliary cholangitis

Bacterial and metabolic phenotypes associated with inadequate response to ursodeoxycholic acid treatment in primary biliary cholangitis

ABSTRACTPrimary biliary cholangitis (PBC) is a chronic cholestatic liver disease with ursodeoxycholic acid (UDCA) as first-line treatment. Poor response to UDCA is associated with a higher risk of progressing to cirrhosis, but the underlying mechanisms are unclear. UDCA modulates the composition of...

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Bibliographic Details
Main Authors: Laura Martinez-Gili, Alexandros Pechlivanis, Julie A.K. McDonald, Sofina Begum, Jonathan Badrock, Jessica K. Dyson, Rebecca Jones, Gideon Hirschfield, Stephen D. Ryder, Richard Sandford, Simon Rushbrook, Douglas Thorburn, Simon D. Taylor-Robinson, Mary M.E. Crossey, Julian R. Marchesi, George Mells, Elaine Holmes, David Jones
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Gut Microbes
Subjects:
Bile acids
gut-liver-kidney axis
microbiota
PBC
UDCA
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2023.2208501

Internet

https://www.tandfonline.com/doi/10.1080/19490976.2023.2208501

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