Polymorphic variants at NDUFC2, encoding a mitochondrial complex I subunit, associate with cardiac hypertrophy in human hypertension

Polymorphic variants at NDUFC2, encoding a mitochondrial complex I subunit, associate with cardiac hypertrophy in human hypertension

Abstract Background A dysfunction of NADH dehydrogenase, the mitochondrial Complex I (CI), associated with the development of left ventricular hypertrophy (LVH) in previous experimental studies. A deficiency of Ndufc2 (subunit of CI) impairs CI activity causing severe mitochondrial dysfunction. The...

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Bibliographic Details
Main Authors: Giovanna Gallo, Maurizio Forte, Maria Cotugno, Simona Marchitti, Rosita Stanzione, Giuliano Tocci, Franca Bianchi, Silvia Palmerio, Mariarosaria Scioli, Giacomo Frati, Sebastiano Sciarretta, Emanuele Barbato, Massimo Volpe, Speranza Rubattu
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Molecular Medicine
Subjects:
Hypertension
Cardiac hypertrophy
NDUFC2
Mitochondrial dysfunction
Mitochondrial complex I
SIRT3
Online Access:https://doi.org/10.1186/s10020-023-00701-x

Internet

https://doi.org/10.1186/s10020-023-00701-x

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