cAMP driven UCP1 induction in human adipocytes requires ATGL-catalyzed lipolysis

cAMP driven UCP1 induction in human adipocytes requires ATGL-catalyzed lipolysis

Objective: The uncoupling protein 1 (UCP1) is induced in brown or “beige” adipocytes through catecholamine-induced cAMP signaling, which activates diverse transcription factors. UCP1 expression can also be enhanced by PPARγ agonists such as rosiglitazone (Rsg). However, it is unclear whether this up...

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Bibliographic Details
Main Authors: Anand Desai, Zinger Yang Loureiro, Tiffany DeSouza, Qin Yang, Javier Solivan-Rivera, Silvia Corvera
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Molecular Metabolism
Subjects:
Thermogenesis
Brown adipose
Beige adipose
Hormone signaling
Catecholamine
Natural ligand
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877824001820

Internet

http://www.sciencedirect.com/science/article/pii/S2212877824001820

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