Neurosteroidal modulation of in vitro epileptiform activity is enhanced in pilocarpine-treated epileptic rats

Neurosteroidal modulation of in vitro epileptiform activity is enhanced in pilocarpine-treated epileptic rats

We employed field potential recordings in brain slices obtained from pilocarpine-treated epileptic (4–5 weeks following a pilocarpine-induced status epilepticus) and age-matched, non-epileptic control (NEC) rats to establish the effects of the neurosteroid allotetrahydrodeoxycorticosterone (THDOC) o...

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Bibliographic Details
Main Authors: Zahra Shiri, Rochelle Herrington, Maxime Lévesque, Massimo Avoli
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:Neurobiology of Disease
Subjects:
Allotetrahydrodeoxycorticosterone
4-Aminopyridine
Epileptogenesis
High frequency oscillations
Pilocarpine
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115000923

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http://www.sciencedirect.com/science/article/pii/S0969996115000923

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