Human Bone Marrow-Derived Mesenchymal Stromal Cells Reduce the Severity of Experimental Necrotizing Enterocolitis in a Concentration-Dependent Manner

Human Bone Marrow-Derived Mesenchymal Stromal Cells Reduce the Severity of Experimental Necrotizing Enterocolitis in a Concentration-Dependent Manner

Necrotizing enterocolitis (NEC) is a devastating gut disease in preterm neonates. In NEC animal models, mesenchymal stromal cells (MSCs) administration has reduced the incidence and severity of NEC. We developed and characterized a novel mouse model of NEC to evaluate the effect of human bone marrow...

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Bibliographic Details
Main Authors: Livia Provitera, Andrea Tomaselli, Genny Raffaeli, Stefania Crippa, Cristina Arribas, Ilaria Amodeo, Silvia Gulden, Giacomo Simeone Amelio, Valeria Cortesi, Francesca Manzoni, Gaia Cervellini, Jacopo Cerasani, Camilla Menis, Nicola Pesenti, Matteo Tripodi, Ludovica Santi, Marco Maggioni, Caterina Lonati, Samanta Oldoni, Francesca Algieri, Felipe Garrido, Maria Ester Bernardo, Fabio Mosca, Giacomo Cavallaro
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cells
Subjects:
necrotizing enterocolitis
neonate
inflammation
human bone marrow mesenchymal stromal cells
mouse model
apoptosis
Online Access:https://www.mdpi.com/2073-4409/12/5/760

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https://www.mdpi.com/2073-4409/12/5/760

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